LYPLA1

Across TCGA cell cohorts, LYPLA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,130 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LYPLA1-associated GO terms across cancer lineages are Negative regulation of protein localization to centrosome, Protein localization to condensed chromosome, and Regulation of mitotic centrosome separation. Each is linked with LYPLA1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LYPLA1-to-partner and partner-to-LYPLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to centrosome grouped by LYPLA1-low versus LYPLA1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPLA1→partner) and Y-score (partner→LYPLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of protein localization to centrosome →	+0.116	+0.737	<.001	<.001	3	11
LARGE_INTESTINE	Protein localization to condensed chromosome →	+0.114	+0.634	<.001	<.001	3	9
STOMACH	Regulation of mitotic centrosome separation →	+0.150	+0.870	<.001	<.001	3	9
BONE	Regulation of telomeric D-loop disassembly →	+0.068	+0.567	.007	.006	3	8
OESOPHAGUS	Anterograde dendritic transport of messenger ribonucleoprotein complex →	+0.144	+0.823	.003	.007	2	9
OESOPHAGUS	Blastocyst growth →	+0.161	+0.710	.003	.006	1	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,130 associations by consensus.

Negative regulation of protein localization to centrosome by LYPLA1 expression — PANCREAS

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