LYPD8

Across TCGA patient cohorts, LYPD8 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LYPD8-associated genes across cancer lineages are MIR8082, RNU6-422P, and RPL31P53. Each is linked with LYPD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD8-to-partner and partner-to-LYPD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8082 grouped by LYPD8-low versus LYPD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD8→partner) and Y-score (partner→LYPD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8082 →	+1.024	+5.146	<.001	.001	3	1
UCEC	RNU6-422P →	+0.672	+4.690	.004	.003	3	1
UCEC	RPL31P53 →	+0.182	+4.551	.006	.009	3	1
UCEC	TEMN3-AS1 →	+0.436	+4.551	<.001	.009	3	1
UCEC	CDV3P1 →	+0.226	+4.211	<.001	.009	3	1
COAD	SNORD3P1 →	+0.438	+5.435	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MIR8082 by LYPD8 expression — UCEC

Explore this box plot interactively →