LYPD8

Across TCGA cell cohorts, LYPD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,302 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LYPD8-associated GO terms across cancer lineages are Endocytic recycling, Vesicle-mediated transport to the plasma membrane, and Regulation of transforming growth factor beta receptor signaling pathway. Each is linked with LYPD8 in more than 6 cancer types. Because this analysis shows association rather than direction, both LYPD8-to-partner and partner-to-LYPD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endocytic recycling grouped by LYPD8-low versus LYPD8-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD8→partner) and Y-score (partner→LYPD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Endocytic recycling →	+0.056	+0.569	<.001	.003	3	7
KIDNEY	Vesicle-mediated transport to the plasma membrane →	+0.045	+0.864	.001	.004	3	7
SKIN	Regulation of transforming growth factor beta receptor signaling pathway →	+0.046	+0.850	<.001	.001	3	6
CNS	Protein localization to vacuole →	+0.044	+0.518	.002	.008	2	6
BREAST	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.049	+1.025	<.001	<.001	3	5
BLOOD_Leukemia	Negative regulation of myoblast fusion →	+0.059	+0.233	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,302 associations by consensus.

Endocytic recycling by LYPD8 expression — CNS

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