LYPD6B

Across TCGA patient cohorts, LYPD6B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD6B-associated genes across cancer lineages are A-Raf_pS299, FASN, and ACC_pS79. Each is linked with LYPD6B in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD6B-to-partner and partner-to-LYPD6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by LYPD6B-low versus LYPD6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD6B→partner) and Y-score (partner→LYPD6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.107	-2.584	.034	.010	3	1
UCEC	FASN →	+0.488	+2.906	.003	.001	3	1
UCEC	ACC_pS79 →	+0.438	+1.700	.002	.044	3	1
UCEC	ACC1 →	+0.542	+3.183	<.001	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.143	-1.687	.045	.044	3	1
UCEC	MEK1 →	+0.372	+2.906	.016	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by LYPD6B expression — UCEC

Explore this box plot interactively →