Across TCGA patient cohorts, LYPD6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD6-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and FOXO3a_pS318_S321. Each is linked with LYPD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD6-to-partner and partner-to-LYPD6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD6→partner) and Y-score (partner→LYPD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.237	-2.999	.018	.035	3	1
UCEC	FoxM1 →	+0.243	+1.906	.019	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-2.212	.028	.010	3	1
UCEC	ACC1 →	+0.354	+1.906	.015	.016	3	1
UCEC	INPP4B →	-0.262	-2.459	.044	.018	3	1
UCEC	JNK2 →	+0.228	+3.331	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

LYPD6 survival (RNA) · tumor vs normal (RNA) · all LYPD6 data types