LYPD5

Across TCGA patient cohorts, LYPD5 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD5-associated genes across cancer lineages are EGFR_pY1068, MEK1, and p62 Lck ligand. Each is linked with LYPD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD5-to-partner and partner-to-LYPD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LYPD5-low versus LYPD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD5→partner) and Y-score (partner→LYPD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.278	-3.321	.034	.010	3	1
UCEC	MEK1 →	+0.439	+3.169	.022	.019	3	1
UCEC	p62 Lck ligand →	+0.432	+3.321	.011	.010	3	1
UCEC	PDCD4 →	-0.663	-2.990	.007	.036	3	1
UCEC	PI3K-p85 →	+0.221	+2.817	.044	.036	3	1
UCEC	Annexin-1 →	+0.808	+3.189	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by LYPD5 expression — UCEC

Explore this box plot interactively →