LYPD4

Across TCGA patient cohorts, LYPD4 mutation is significantly associated with the RNA expression of many other genes, with 592 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD4-associated genes across cancer lineages are OR4C4P, CHAC1, and SERTM2. Each is linked with LYPD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD4-to-partner and partner-to-LYPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4C4P grouped by LYPD4-low versus LYPD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD4→partner) and Y-score (partner→LYPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR4C4P →	+0.012	+4.769	<.001	.002	3	2
UCEC	CHAC1 →	+0.982	+3.595	.001	.001	3	2
SKCM	SERTM2 →	+0.766	+2.699	<.001	.007	3	2
UCEC	GPT2 →	+0.797	+3.606	<.001	.001	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
BRCA	RNU6-153P →	+0.368	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 592 associations by consensus.

OR4C4P by LYPD4 expression — SKCM

Explore this box plot interactively →