LYPD4

Across TCGA patient cohorts, LYPD4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD4-associated genes across cancer lineages are PREX1, Notch1, and PDCD4. Each is linked with LYPD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD4-to-partner and partner-to-LYPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by LYPD4-low versus LYPD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD4→partner) and Y-score (partner→LYPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PREX1 →	-0.479	-3.169	.007	.018	3	1
UCEC	Notch1 →	+0.207	+2.817	.005	.036	3	1
UCEC	PDCD4 →	-0.738	-2.990	.002	.036	3	1
UCEC	MEK1 →	+0.450	+3.321	.018	.010	1	1
UCEC	NDRG1_pT346 →	-0.610	-3.321	.017	.010	1	1
UCEC	Annexin-1 →	+0.707	+3.321	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PREX1 by LYPD4 expression — SKCM

Explore this box plot interactively →