LYPD4

Across TCGA cell cohorts, LYPD4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LYPD4-associated genes across cancer lineages are TRIM48, OR52K1, and P2RY13. Each is linked with LYPD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD4-to-partner and partner-to-LYPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM48 grouped by LYPD4-low versus LYPD4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD4→partner) and Y-score (partner→LYPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM48 →	+0.053	+4.269	<.001	.005	3	1
LUNG_SCLC	OR52K1 →	+0.005	+4.643	<.001	.004	3	1
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	1
SKIN	MBD3L5 →	+0.026	+5.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TRIM48 by LYPD4 expression — LUNG_SCLC

Explore this box plot interactively →