LYPD3

Across TCGA patient cohorts, LYPD3 mutation is significantly associated with the RNA expression of many other genes, with 1,080 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD3-associated genes across cancer lineages are LINC02558, CCNDBP1, and PPIP5K1. Each is linked with LYPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD3-to-partner and partner-to-LYPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02558 grouped by LYPD3-low versus LYPD3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD3→partner) and Y-score (partner→LYPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02558 →	+0.155	+5.669	.007	.003	3	2
SKCM	CCNDBP1 →	+0.667	+3.366	.002	.005	3	2
SKCM	PPIP5K1 →	+0.820	+3.198	<.001	.009	3	2
SKCM	ZNF57 →	+0.564	+3.366	.003	.005	3	2
BLCA	ANAPC1P3 →	+0.105	+3.719	.006	.008	3	2
BLCA	BMS1P3 →	+0.103	+3.758	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

LINC02558 by LYPD3 expression — CESC

Explore this box plot interactively →