LYPD3

Across TCGA cell cohorts, LYPD3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LYPD3-associated genes across cancer lineages are LILRA1, BPIFA1, and PRR32. Each is linked with LYPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD3-to-partner and partner-to-LYPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA1 grouped by LYPD3-low versus LYPD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD3→partner) and Y-score (partner→LYPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LILRA1 →	+0.013	+4.095	.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.178	+4.273	<.001	.006	3	1
LUNG_SCLC	PRR32 →	+0.034	+3.256	<.001	.005	3	1
LUNG_SCLC	OFCC1 →	+0.888	+3.479	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

LILRA1 by LYPD3 expression — LARGE_INTESTINE

Explore this box plot interactively →