LYPD1

Across TCGA patient cohorts, LYPD1 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPD1-associated genes across cancer lineages are NPLP1, POLR3KP2, and MFSD4BP1. Each is linked with LYPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPD1-to-partner and partner-to-LYPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPLP1 grouped by LYPD1-low versus LYPD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD1→partner) and Y-score (partner→LYPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NPLP1 →	+0.214	+5.080	<.001	.008	3	2
COAD	POLR3KP2 →	+0.431	+6.003	<.001	.002	3	2
UCEC	MFSD4BP1 →	+0.120	+2.943	.007	.003	3	2
UCEC	CYCSP26 →	+0.141	+3.299	.003	.006	3	2
SKCM	TRAJ23 →	+0.597	+4.531	.004	.005	3	2
SKCM	MTCYBP36 →	+0.077	+5.080	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

NPLP1 by LYPD1 expression — COAD

Explore this box plot interactively →