LYNX1

Across TCGA patient cohorts, LYNX1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYNX1-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and EGFR_pY1068. Each is linked with LYNX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYNX1-to-partner and partner-to-LYNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by LYNX1-low versus LYNX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYNX1→partner) and Y-score (partner→LYNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.342	+2.594	.008	.006	3	2
UCEC	14-3-3_beta →	-0.080	-2.973	.047	.035	3	1
UCEC	EGFR_pY1068 →	-0.271	-2.415	.007	.003	3	1
UCEC	A-Raf_pS299 →	-0.110	-1.906	.022	.016	3	1
UCEC	ERK2 →	+0.171	+1.906	.027	.016	3	1
UCEC	JNK2 →	+0.334	+3.087	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p62 Lck ligand by LYNX1 expression — UCEC

Explore this box plot interactively →