Across TCGA patient cohorts, LYG2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYG2-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and CDK1. Each is linked with LYG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYG2-to-partner and partner-to-LYG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYG2→partner) and Y-score (partner→LYG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.345	+2.584	<.001	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.871	+2.341	.001	.019	3	2
UCEC	CDK1 →	+0.193	+2.820	.006	.035	3	2
UCEC	EGFR_pY1068 →	-0.343	-2.584	.003	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.238	-2.571	.002	.011	3	1
UCEC	JNK2 →	+0.374	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

LYG2 survival (RNA) · tumor vs normal (RNA) · all LYG2 data types