LYG1

Across TCGA patient cohorts, LYG1 mutation is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LYG1-associated genes across cancer lineages are TRGJP1, RPSAP10, and IFNNP1. Each is linked with LYG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYG1-to-partner and partner-to-LYG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP1 grouped by LYG1-low versus LYG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYG1→partner) and Y-score (partner→LYG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRGJP1 →	+0.642	+3.584	.001	.002	3	2
COAD	RPSAP10 →	+0.235	+3.683	.006	.007	3	2
COAD	IFNNP1 →	+0.066	+5.087	<.001	.002	3	2
SKCM	GAPDHP30 →	+0.064	+3.521	.001	.002	3	2
UCEC	NIPA2P3 →	+0.060	+4.359	.008	<.001	3	1
UCEC	COX6CP3 →	+0.212	+3.092	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

TRGJP1 by LYG1 expression — COAD

Explore this box plot interactively →