LYAR

Across TCGA patient cohorts, LYAR protein abundance is significantly associated with the RNA expression of many other genes, with 15,797 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LYAR-associated genes across cancer lineages are PBXIP1, MYBL2, and UBE2C. Each is linked with LYAR in more than 6 cancer types. Because this analysis shows association rather than direction, both LYAR-to-partner and partner-to-LYAR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LYAR versus PBXIP1 in HNSC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYAR→partner) and Y-score (partner→LYAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PBXIP1 →	-0.736	-0.260	.004	<.001	3	7
UCEC	MYBL2 →	+1.700	+0.477	<.001	<.001	3	7
CCRCC	UBE2C →	+1.543	+0.301	<.001	<.001	3	7
LUAD	AURKA →	+1.067	+0.290	<.001	.001	3	7
UCEC	TPX2 →	+1.397	+0.510	<.001	<.001	3	7
BRCA	BIRC5 →	+1.013	+0.332	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,797 associations by consensus.

LYAR vs PBXIP1 — HNSC

Explore this scatter interactively →