LYAR

Across TCGA patient cohorts, LYAR mutation is significantly associated with the RNA expression of many other genes, with 903 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYAR-associated genes across cancer lineages are AKIRIN2P1, CCER2, and LINC02210-CRHR1. Each is linked with LYAR in more than 1 cancer types. Because this analysis shows association rather than direction, both LYAR-to-partner and partner-to-LYAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKIRIN2P1 grouped by LYAR-low versus LYAR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYAR→partner) and Y-score (partner→LYAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AKIRIN2P1 →	+0.544	+4.510	<.001	.005	3	2
UCEC	CCER2 →	-0.624	-2.785	.005	.003	3	1
UCEC	LINC02210-CRHR1 →	+0.096	+3.022	<.001	<.001	3	1
UCEC	MIR3193 →	+0.599	+2.101	<.001	.008	3	1
UCEC	FCGR1CP →	+0.775	+3.740	<.001	<.001	3	1
UCEC	MYO15B →	-0.887	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

AKIRIN2P1 by LYAR expression — COAD

Explore this box plot interactively →