LYAR

Across TCGA cell cohorts, LYAR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,665 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LYAR-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Ribosomal small subunit biogenesis, and Maturation of LSU-rRNA. Each is linked with LYAR in more than 18 cancer types. Because this analysis shows association rather than direction, both LYAR-to-partner and partner-to-LYAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by LYAR-low versus LYAR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYAR→partner) and Y-score (partner→LYAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of SSU-rRNA →	+0.147	+1.091	<.001	<.001	3	19
BONE	Ribosomal small subunit biogenesis →	+0.125	+1.188	<.001	<.001	3	19
BONE	Maturation of LSU-rRNA →	+0.179	+1.085	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	'de novo' IMP biosynthetic process →	+0.225	+1.529	<.001	<.001	3	19
BLOOD_Myeloma	DNA replication initiation →	+0.192	+1.046	<.001	<.001	3	19
LUNG_SCLC	RNA 5'-end processing →	+0.090	+0.892	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,665 associations by consensus.

Maturation of SSU-rRNA by LYAR expression — BONE

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