LYAR

Across TCGA cell cohorts, LYAR mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LYAR-associated genes across cancer lineages are SMIM23, CSHL1, and PIRT. Each is linked with LYAR in more than 1 cancer types. Because this analysis shows association rather than direction, both LYAR-to-partner and partner-to-LYAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by LYAR-low versus LYAR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYAR→partner) and Y-score (partner→LYAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM23 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	CSHL1 →	+0.018	+5.539	.001	.003	3	1
SKIN	PIRT →	+0.136	+4.095	<.001	.009	3	1
SKIN	PRAMEF27 →	+0.034	+4.095	.001	.009	3	1
SKIN	TNMD →	+0.093	+4.684	<.001	.002	3	1
CNS	DUSP29 →	+0.035	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SMIM23 by LYAR expression — BLOOD_Leukemia

Explore this box plot interactively →