LY9

Across TCGA patient cohorts, LY9 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY9-associated genes across cancer lineages are PDCD4, NF2, and 4E-BP1. Each is linked with LY9 in more than 3 cancer types. Because this analysis shows association rather than direction, both LY9-to-partner and partner-to-LY9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by LY9-low versus LY9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY9→partner) and Y-score (partner→LY9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.580	-2.000	<.001	.003	3	4
LUAD	NF2 →	+0.555	+3.169	<.001	.019	3	2
UCEC	4E-BP1 →	+0.400	+3.523	<.001	<.001	3	2
UCEC	ERK2 →	+0.162	+1.362	.017	.037	3	2
UCEC	p62 Lck ligand →	+0.316	+2.392	.005	<.001	3	2
UCEC	PCNA →	+0.236	+2.087	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PDCD4 by LY9 expression — UCEC

Explore this box plot interactively →