LY86

Across TCGA patient cohorts, LY86 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY86-associated genes across cancer lineages are Rictor_pT1135, Tuberin, and eIF4E. Each is linked with LY86 in more than 1 cancer types. Because this analysis shows association rather than direction, both LY86-to-partner and partner-to-LY86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by LY86-low versus LY86-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY86→partner) and Y-score (partner→LY86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.137	-3.169	.014	.020	3	1
UCEC	Tuberin →	+0.407	+3.009	.005	.019	3	1
UCEC	eIF4E →	+0.286	+3.169	.013	.020	2	1
UCEC	TIGAR →	+0.216	+3.196	.010	.010	1	2
UCEC	eEF2 →	+0.559	+3.169	.004	.020	1	1
UCEC	EGFR_pY1068 →	-0.284	-3.169	.039	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Rictor_pT1135 by LY86 expression — UCEC

Explore this box plot interactively →