LY75

Across TCGA pan-cancer cohorts, LY75 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LY75’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LY75 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LY75 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where LY75 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LY75 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.566	<.001	6	view →
LSCC	Male	II,III,IV	−0.535	<.001	6	view →
PDAC	All	All	+0.413	.001	4	view →
CCRCC	All	All	+0.539	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

LY75–LUAD

Open the LUAD breakdown →