LY6K

Across TCGA pan-cancer cohorts, LY6K mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LY6K’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LY6K mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LY6K is over-expressed in tumor.

HNSC and LSCC are the cancer types where LY6K tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LY6K mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.012	<.001	8	view →
LSCC	All	All	+1.014	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LY6K–HNSC

Open the HNSC breakdown →