LY6K

Across TCGA patient cohorts, LY6K mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY6K-associated genes across cancer lineages are Annexin-1, C-Raf, and 14-3-3_beta. Each is linked with LY6K in more than 1 cancer types. Because this analysis shows association rather than direction, both LY6K-to-partner and partner-to-LY6K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by LY6K-low versus LY6K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6K→partner) and Y-score (partner→LY6K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.573	+2.604	.005	.005	3	2
UCEC	C-Raf →	+0.119	+2.000	.033	.030	3	2
UCEC	14-3-3_beta →	-0.081	-2.973	.040	.035	3	1
UCEC	EGFR_pY1068 →	-0.210	-2.115	.033	.017	3	1
UCEC	ERK2 →	+0.184	+2.459	.014	.018	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.330	+2.000	.049	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Annexin-1 by LY6K expression — UCEC

Explore this box plot interactively →