LY6G6E

Across TCGA pan-cancer cohorts, LY6G6E RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LY6G6E’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LY6G6E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LY6G6E is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

COAD, LUAD, and LUSC are the cancer types where LY6G6E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LY6G6E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.790	<.001	10	view →
LUAD	Female	All	−0.310	<.001	9	view →
LUSC	All	All	−0.296	<.001	6	view →
KIRC	All	All	+0.024	.001	4	view →
READ	All	All	+0.496	.011	2	view →
PAAD	Male	All	+0.115	.016	2	view →
UCEC	All	All	+0.110	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

LY6G6E–COAD

Open the COAD breakdown →