LY6E-DT

Across TCGA pan-cancer cohorts, LY6E-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LY6E-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LY6E-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LY6E-DT expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, KIRP, and ACC are the cancer types where LY6E-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.742	0.561	<.001	102	view →
KIRP	DFS	Median	III,IV	0.533	0.895	<.001	56	view →
ACC	OS	Median	All	0.955	0.668	.001	46	view →
PAAD	DFS	Median	All	0.213	0.523	<.001	40	view →
GBM	OS	Quartile	All	0.204	0.338	.007	30	view →
UCS	DFS	Tertile	IV	0.275	0.906	.024	24	view →
COAD	DFS	Quartile	II,III,IV	0.359	0.644	.007	17	view →
UVM	OS	Median	All	0.425	0.839	.019	14	view →
CESC	OS	Median	II,III,IV	0.904	0.738	.008	14	view →
UCEC	DFS	Quartile	All	0.533	0.833	.002	14	view →
KICH	OS	Quartile	II,III,IV	0.484	0.942	.009	11	view →
CHOL	OS	Median	All	0.876	0.456	.019	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LY6E-DT–KIRC (DFS)

Open the KIRC breakdown →