LUZP4

Across TCGA patient cohorts, LUZP4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LUZP4-associated genes across cancer lineages are INPP4B, C-Raf, and EGFR_pY1068. Each is linked with LUZP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LUZP4-to-partner and partner-to-LUZP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by LUZP4-low versus LUZP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUZP4→partner) and Y-score (partner→LUZP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.295	-2.807	.004	.002	3	2
UCEC	C-Raf →	+0.105	+1.222	.023	.035	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.716	.010	.003	3	1
UCEC	EGFR →	-0.199	-2.880	<.001	.001	3	1
UCEC	eIF4G →	+0.326	+2.000	.001	.009	3	1
UCEC	FoxM1 →	+0.255	+2.000	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

INPP4B by LUZP4 expression — UCEC

Explore this box plot interactively →