LUZP1

Across TCGA patient cohorts, LUZP1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LUZP1-associated genes across cancer lineages are eEF2, GAPDH, and Caspase-7-cleavedD198. Each is linked with LUZP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LUZP1-to-partner and partner-to-LUZP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LUZP1-low versus LUZP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUZP1→partner) and Y-score (partner→LUZP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.327	+1.206	<.001	.009	3	3
COAD	GAPDH →	+0.711	+2.008	<.001	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.414	+2.338	<.001	.017	3	3
COAD	FASN →	+0.490	+2.008	.001	.018	3	2
UCEC	MEK1 →	+0.412	+1.722	<.001	<.001	3	2
COAD	p53 →	-0.334	-3.321	.010	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eEF2 by LUZP1 expression — UCEC

Explore this box plot interactively →