Q-omics provides the consensus-scored LUNAR1 profile across patient tissues and cancer cell-line models. LUNAR1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, LUNAR1 is differentially expressed in 8, with the highest sampling consensus in HNSC. Additionally, LUNAR1 RNA expression shows 16,476 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight COAD, HNSC, and UVM as cancer lineages where LUNAR1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LUNAR1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LUNAR1 survival associations across molecular data types. LUNAR1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LUNAR1 RNA expression–survival associations across cancer types. High LUNAR1 expression shows unfavorable associations in COAD, UVM and ACC, but favorable associations in OV, UCS and LUSC. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify COAD as the clearest survival context for LUNAR1 RNA expression.
This table summarizes LUNAR1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LUNAR1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LUNAR1 shows higher tumor expression in HNSC, LUSC, BLCA, COAD, CHOL and KIRC. The HNSC box plot shows higher LUNAR1 RNA expression in tumor versus normal tissue (log2 FC = +0.065, t-test p = .003).
This table shows molecular features associated with LUNAR1 in patient tissues and cancer cell lines. In patient samples, LUNAR1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
