LUM

Across TCGA pan-cancer cohorts, LUM mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LUM data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LUM mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LUM expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where LUM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.795	1.000	.005	30	view →
CCRCC	DFS	Median	II,III,IV	0.199	0.839	.011	13	view →
LSCC	DFS	Median	II,III,IV	0.821	1.000	.002	9	view →
GBM	OS	Quartile	All	0.242	0.533	.019	4	view →
PDAC	DFS	Quartile	All	0.800	0.643	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LUM–LUAD (OS)

Open the LUAD breakdown →