LUM

Across TCGA patient cohorts, LUM protein abundance is significantly associated with the RNA expression of many other genes, with 18,467 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LUM-associated genes across cancer lineages are MGP, C7, and PDGFRB. Each is linked with LUM in more than 9 cancer types. Because this analysis shows association rather than direction, both LUM-to-partner and partner-to-LUM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LUM versus MGP in COAD, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUM→partner) and Y-score (partner→LUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MGP →	+1.956	+0.875	<.001	<.001	3	10
OV	C7 →	+2.332	+0.718	<.001	.003	3	10
OV	PDGFRB →	+1.549	+0.937	<.001	<.001	3	10
CCRCC	DCN →	+1.800	+0.614	<.001	<.001	3	10
OV	AOC3 →	+1.630	+0.990	<.001	<.001	3	10
CCRCC	FBLN5 →	+1.302	+1.017	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,467 associations by consensus.

LUM vs MGP — COAD

Explore this scatter interactively →