LUM

Across TCGA patient cohorts, LUM mutation is significantly associated with the RNA expression of many other genes, with 1,607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LUM-associated genes across cancer lineages are MIR4445, RNA5SP146, and MIR4643. Each is linked with LUM in more than 2 cancer types. Because this analysis shows association rather than direction, both LUM-to-partner and partner-to-LUM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by LUM-low versus LUM-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUM→partner) and Y-score (partner→LUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4445 →	+0.237	+4.309	.002	.007	3	3
HNSC	RNA5SP146 →	+0.604	+5.124	<.001	.008	3	3
BRCA	MIR4643 →	+0.341	+7.731	<.001	.009	3	2
LUSC	RPS27AP14 →	+0.105	+3.932	<.001	.003	3	2
UCEC	EOLA1 →	+0.390	+2.338	.004	.003	3	2
UCEC	KIFBP →	+0.436	+1.958	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,607 associations by consensus.

MIR4445 by LUM expression — LUSC

Explore this box plot interactively →