LUM

Across TCGA patient cohorts, LUM mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LUM-associated genes across cancer lineages are Rad50, Akt_pT308, and ASNS. Each is linked with LUM in more than 1 cancer types. Because this analysis shows association rather than direction, both LUM-to-partner and partner-to-LUM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by LUM-low versus LUM-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUM→partner) and Y-score (partner→LUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Rad50 →	-0.154	-2.924	.047	.035	3	2
UCEC	Akt_pT308 →	+0.538	+2.415	.033	.003	3	2
UCEC	ASNS →	+0.420	+3.321	.003	.009	3	2
UCEC	ATM →	-0.531	-3.156	.003	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.855	+2.415	<.001	.003	3	2
LUAD	S6_pS240_S244 →	-0.907	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Rad50 by LUM expression — LUAD

Explore this box plot interactively →