LUM

Across TCGA cell cohorts, LUM RNA expression is significantly associated with the go_rna of many other GO terms, with 2,910 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LUM-associated GO terms across cancer lineages are Positive regulation of amyloid-beta clearance, Vesicle cargo loading, and Maintenance of protein location. Each is linked with LUM in more than 6 cancer types. Because this analysis shows association rather than direction, both LUM-to-partner and partner-to-LUM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of amyloid-beta clearance grouped by LUM-low versus LUM-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LUM→partner) and Y-score (partner→LUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of amyloid-beta clearance →	+0.187	+2.208	<.001	.006	3	7
BONE	Vesicle cargo loading →	+0.137	+5.276	<.001	<.001	3	7
BREAST	Maintenance of protein location →	+0.132	+2.225	<.001	.009	3	7
BONE	Regulation of proteolysis →	+0.090	+3.700	<.001	<.001	3	7
SOFT_TISSUE	Articular cartilage development →	+1.084	+4.194	<.001	<.001	3	6
LIVER	Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway →	+0.301	+4.174	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,910 associations by consensus.

Positive regulation of amyloid-beta clearance by LUM expression — OVARY

Explore this box plot interactively →