LUM

Across TCGA cell cohorts, LUM mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LUM-associated genes across cancer lineages are GSG1L2, MYH1, and SPZ1. Each is linked with LUM in more than 1 cancer types. Because this analysis shows association rather than direction, both LUM-to-partner and partner-to-LUM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by LUM-low versus LUM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUM→partner) and Y-score (partner→LUM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	2
LUNG_NSCLC_LUAD	MYH1 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPZ1 →	+0.010	+3.734	<.001	.006	3	1
BREAST	CFHR4 →	+0.167	+3.772	.001	.007	3	1
BREAST	CFC1 →	+0.017	+3.672	.003	.006	3	1
BREAST	CFC1B →	+0.004	+4.196	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

GSG1L2 by LUM expression — BLOOD_Leukemia

Explore this box plot interactively →