LUC7L3

Across TCGA patient cohorts, LUC7L3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LUC7L3-associated genes across cancer lineages are ASNS, eEF2, and A-Raf_pS299. Each is linked with LUC7L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LUC7L3-to-partner and partner-to-LUC7L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LUC7L3-low versus LUC7L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LUC7L3→partner) and Y-score (partner→LUC7L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.415	+2.000	.003	.030	3	2
UCEC	eEF2 →	+0.433	+3.584	.002	.002	3	1
UCEC	A-Raf_pS299 →	-0.144	-2.700	.002	.006	3	1
UCEC	ERK2 →	+0.192	+2.000	.011	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.150	-1.584	.002	.036	3	1
UCEC	GATA6 →	-0.141	-1.899	.023	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ASNS by LUC7L3 expression — UCEC

Explore this box plot interactively →