LTV1

Across TCGA patient cohorts, LTV1 mutation is significantly associated with the RNA expression of many other genes, with 2,561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTV1-associated genes across cancer lineages are OXA1L, SUPV3L1, and CCDC51. Each is linked with LTV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LTV1-to-partner and partner-to-LTV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXA1L grouped by LTV1-low versus LTV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTV1→partner) and Y-score (partner→LTV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OXA1L →	+0.314	+2.457	<.001	.001	3	2
UCEC	SUPV3L1 →	+0.338	+2.470	.004	<.001	3	2
UCEC	CCDC51 →	+0.460	+3.828	.002	<.001	3	2
UCEC	VDAC2 →	+0.475	+2.081	.002	.001	3	2
UCEC	PMPCA →	+0.538	+2.970	<.001	<.001	3	2
UCEC	ATMIN →	+0.387	+2.102	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,561 associations by consensus.

OXA1L by LTV1 expression — UCEC

Explore this box plot interactively →