LTO1

Across TCGA patient cohorts, LTO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,692 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LTO1-associated proteins across cancer lineages are WDR5, KIF13B, and DHX9. Each is linked with LTO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LTO1-to-partner and partner-to-LTO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LTO1 versus WDR5 in LSCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LTO1→partner) and Y-score (partner→LTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR5 →	+0.330	+0.856	<.001	<.001	3	5
UCEC	KIF13B →	-0.496	-0.448	<.001	<.001	3	5
HNSC	DHX9 →	+0.231	+1.312	<.001	<.001	3	5
LSCC	LIG3 →	+0.470	+0.930	<.001	<.001	3	5
GBM	POGZ →	+0.252	+0.312	<.001	<.001	3	5
HNSC	XPO1 →	+0.200	+0.869	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,692 associations by consensus.

LTO1 vs WDR5 — LSCC

Explore this scatter interactively →