LTO1

Across TCGA patient cohorts, LTO1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,077 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LTO1-associated genes across cancer lineages are NDUFAF4P2, ZNRF2P2, and GAPDHP27. Each is linked with LTO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LTO1-to-partner and partner-to-LTO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LTO1 versus NDUFAF4P2 in HNSC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTO1→partner) and Y-score (partner→LTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NDUFAF4P2 →	+0.993	+0.592	<.001	<.001	2	3
GBM	ZNRF2P2 →	+1.926	+0.633	.003	.005	3	2
GBM	GAPDHP27 →	+1.109	+0.484	.009	.006	3	2
GBM	CIBAR2 →	-1.748	-0.473	.005	.006	3	2
LSCC	RNU6-661P →	+0.849	+0.505	<.001	.002	3	2
GBM	CCDC85C →	+0.549	+0.583	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,077 associations by consensus.

LTO1 vs NDUFAF4P2 — HNSC

Explore this scatter interactively →