LTO1

Across TCGA patient cohorts, LTO1 mutation is significantly associated with the RNA expression of many other genes, with 830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTO1-associated genes across cancer lineages are RNA5SP369, HSD17B12, and KLHL35. Each is linked with LTO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LTO1-to-partner and partner-to-LTO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by LTO1-low versus LTO1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTO1→partner) and Y-score (partner→LTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP369 →	+0.589	+5.539	<.001	.004	3	2
UCEC	HSD17B12 →	+0.610	+3.606	.004	.001	3	1
UCEC	KLHL35 →	+0.798	+3.700	.001	.001	3	1
UCEC	MTA2 →	+0.461	+3.764	.004	<.001	3	1
UCEC	TIRAP →	+0.541	+3.346	.003	.005	3	1
UCEC	PRSS53 →	+0.275	+2.660	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 830 associations by consensus.

RNA5SP369 by LTO1 expression — CESC

Explore this box plot interactively →