LTO1

Across TCGA patient cohorts, LTO1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTO1-associated genes across cancer lineages are GSK-3_pS9, GSK-3a-b_pS21_S9, and MEK1. Each is linked with LTO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LTO1-to-partner and partner-to-LTO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by LTO1-low versus LTO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTO1→partner) and Y-score (partner→LTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	+0.502	+2.321	.013	.035	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.543	+2.331	.011	.019	3	1
UCEC	MEK1 →	+0.414	+3.459	.024	.005	3	1
UCEC	Rad50 →	-0.322	-2.321	.008	.035	3	1
UCEC	Annexin-1 →	+0.582	+2.827	.028	.035	3	1
UCEC	Tuberin_pT1462 →	+0.380	+2.179	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GSK-3_pS9 by LTO1 expression — UCEC

Explore this box plot interactively →