LTO1

Across TCGA cell cohorts, LTO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,306 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LTO1-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, CAAX-box protein processing, and Cellular response to platelet-derived growth factor stimulus. Each is linked with LTO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both LTO1-to-partner and partner-to-LTO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by LTO1-low versus LTO1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LTO1→partner) and Y-score (partner→LTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of mRNA splicing, via spliceosome →	+0.090	+0.992	<.001	<.001	3	13
BONE	CAAX-box protein processing →	+0.172	+0.968	<.001	.001	3	13
SOFT_TISSUE	Cellular response to platelet-derived growth factor stimulus →	+0.139	+0.684	<.001	<.001	3	12
LARGE_INTESTINE	mRNA cis splicing, via spliceosome →	+0.086	+0.715	<.001	.001	3	12
OESOPHAGUS	Regulation of translational initiation →	+0.091	+1.401	.001	.004	3	12
BONE	Recombinational repair →	+0.102	+1.201	.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,306 associations by consensus.

Regulation of mRNA splicing, via spliceosome by LTO1 expression — LARGE_INTESTINE

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