Across TCGA patient cohorts, LTN1 mutation is significantly associated with the RNA expression of many other genes, with 4,980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTN1-associated genes across cancer lineages are NDUFA8, EMC6, and PSRC1. Each is linked with LTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LTN1-to-partner and partner-to-LTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTN1→partner) and Y-score (partner→LTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA8 →	+0.284	+1.362	<.001	<.001	3	4
UCEC	EMC6 →	+0.492	+2.459	<.001	<.001	3	4
UCEC	PSRC1 →	+0.474	+1.351	.001	<.001	3	4
UCEC	CAMTA1 →	+0.206	+1.839	.006	.002	3	4
CESC	CCDC116 →	+0.217	+3.239	<.001	.008	3	3
LUSC	EBNA1BP2 →	+0.472	+3.404	.003	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,980 associations by consensus.

Exploration

LTN1 survival (RNA) · tumor vs normal (RNA) · all LTN1 data types