Across TCGA patient cohorts, LTN1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTN1-associated genes across cancer lineages are FASN, FoxM1, and FOXO3a_pS318_S321. Each is linked with LTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LTN1-to-partner and partner-to-LTN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTN1→partner) and Y-score (partner→LTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FASN →	+0.517	+3.000	.009	.034	3	4
UCEC	FoxM1 →	+0.180	+1.584	.014	.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.082	-1.575	.020	.004	3	3
UCEC	ACC1 →	+0.263	+1.515	.011	.015	3	3
UCEC	Src_pY527 →	-0.286	-1.280	.019	.049	3	3
UCEC	Caspase-7-cleavedD198 →	+0.413	+1.090	.014	.037	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

LTN1 survival (RNA) · tumor vs normal (RNA) · all LTN1 data types