Across TCGA pan-cancer cohorts, LTC4S Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LTC4S data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher LTC4S Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LTC4S expression acts as an unfavorable survival marker.

ESCA and PRAD are the cancer types where LTC4S Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.102	0.703	<.001	36	view →
PRAD	DFS	Median	All	0.135	0.774	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: LTC4S tumor-vs-normal RNA expression · all LTC4S data types