Across TCGA pan-cancer cohorts, LTC4S mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LTC4S data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LTC4S mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LTC4S expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where LTC4S mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.941	0.603	.010	18	view →
PDAC	OS	Tertile	All	0.966	0.671	.005	8	view →
CCRCC	DFS	Median	All	0.815	0.586	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: LTC4S tumor-vs-normal RNA expression · all LTC4S data types