LTBR

Across TCGA pan-cancer cohorts, LTBR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LTBR data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LTBR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LTBR expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where LTBR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.709	0.989	.003	17	view →
PDAC	DFS	Tertile	All	0.259	0.496	.003	9	view →
HNSC	DFS	Median	IV	0.915	1.000	.020	3	view →
GBM	OS	Tertile	All	0.489	0.712	.021	2	view →
LUAD	OS	Quartile	II,III,IV	0.401	1.000	.010	2	view →
LSCC	DFS	Tertile	II,III,IV	0.953	0.803	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LTBR–CCRCC (OS)

Open the CCRCC breakdown →