LTBR

Across TCGA pan-cancer cohorts, LTBR mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LTBR’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LTBR mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LTBR is over-expressed in tumor.

COAD, PDAC, and LSCC are the cancer types where LTBR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LTBR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.443	<.001	10	view →
PDAC	Female	II,III,IV	+0.884	<.001	8	view →
LSCC	Male	III,IV	+0.696	<.001	8	view →
HNSC	Male	III,IV	+0.494	<.001	8	view →
LUAD	Male	II,III,IV	+0.491	<.001	8	view →
CCRCC	All	II,III,IV	+0.348	.004	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LTBR–COAD

Open the COAD breakdown →