LTBR

Across TCGA patient cohorts, LTBR mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTBR-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Ku80. Each is linked with LTBR in more than 1 cancer types. Because this analysis shows association rather than direction, both LTBR-to-partner and partner-to-LTBR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LTBR-low versus LTBR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBR→partner) and Y-score (partner→LTBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.117	-2.973	.012	.035	3	1
UCEC	ERK2 →	+0.190	+2.999	.034	.035	3	1
UCEC	Ku80 →	+0.311	+3.013	.004	.018	3	1
UCEC	p21 →	+0.194	+2.820	.030	.035	3	1
UCEC	PCNA →	+0.266	+2.584	.008	.011	3	1
UCEC	Annexin-1 →	+0.760	+3.019	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

14-3-3_beta by LTBR expression — UCEC

Explore this box plot interactively →