LTBP4

Across TCGA patient cohorts, LTBP4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTBP4-associated genes across cancer lineages are C-Raf, Caspase-7-cleavedD198, and Caspase-8. Each is linked with LTBP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LTBP4-to-partner and partner-to-LTBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by LTBP4-low versus LTBP4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP4→partner) and Y-score (partner→LTBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C-Raf →	+0.246	+3.321	.008	.010	3	3
COAD	Caspase-7-cleavedD198 →	+0.818	+3.016	.013	.018	3	3
UCEC	Caspase-8 →	-0.270	-2.000	<.001	<.001	3	2
LUSC	MSH6 →	+0.572	+2.816	.010	.036	3	2
UCEC	eIF4E →	+0.177	+2.137	.003	<.001	3	2
UCEC	ERK2 →	+0.136	+1.662	.013	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

C-Raf by LTBP4 expression — BLCA

Explore this box plot interactively →